Monograph Details
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Immune System
> Immunization
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PROQUAD |
| Manufacturer |
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Merck & Co., Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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MMR+Var. |
| Generic Name |
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Measles, mumps, rubella, and varicella viruses live, attenuated; pwd for SC inj after reconstitution; contains neomycin (trace), human albumin; preservative-free. |
| Indications |
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Measles, mumps, rubella, and varicella immunization; it may be used if a 2nd dose of measles, mumps, and rubella vaccine is to be administered. |
| Children |
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<12 months: not recommended. 12 mos–12 yrs: 0.5mL SC once into upper outer arm or upper anterolateral thigh. |
| Adults |
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Not recommended. |
| Contraindications |
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Egg, gelatin, or neomycin hypersensitivity. Blood dyscrasias. Bone marrow or lymphatic malignancy. Immunosuppression. Active untreated tuberculosis. Fever >101.3°F. Pregnancy (Cat.C); avoid pregnancy for 3 months after vaccination. Nursing mothers. |
| Precautions |
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Have epinephrine inj (1:1000) available. History of febrile convulsions or cerebral injury. Thrombocytopenia. Avoid contact with high-risk persons susceptible to varicella for 6 wks after vaccination. |
| Interactions |
Immunosuppressants (see Contraindications). Avoid salicylates for
6 weeks after vaccination. Defer vaccination for at least 3 months after blood or plasma transfusions or immune globulins. Avoid immune globulin administration for 1 month after vaccination. Separate dosing of measles-containing vaccine by 1 month. If 2nd dose of varicella-containing vaccine needed, separate by 3 months. Concomitant other vaccines: see literature. May interfere with tuberculin skin test. |
| Adverse Reactions |
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Inj site reactions, fever, irritability, rash; others. |
| Extra Text |
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Note: Register pregnant patients exposed to ProQuad by calling (800) 986-8999. Report adverse events to VAERS by calling (800) 822-7967. |
| How Supplied |
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Single-dose vials—1, 10 (w. diluent) |
| Additional Resources |
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• Related Prescribing Note |
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