Monograph Details

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Immune System > Immunization

INFANRIX

Manufacturer

GlaxoSmithKline Pharmaceuticals

Legal Classification

Pharmacological Class

DTaP.

Generic Name

Diphtheria and tetanus toxoids, acellular pertussis vaccine; aluminum hydroxide adsorbed; IM inj; preservative-free.

Indications

Diphtheria, tetanus, and pertussis immunization in children 6 weeks up to 7 years of age (before 7^th birthday).

Children

Each dose is 0.5mL IM. Primary series: Give 1^st dose preferably at 2 months of age (may give as early as 6 wks of age); then give 2^nddose 4–8 wks later, then give 3^rddose 4–8 wks later, then give 4^th dose at 15–20 months of age (6–12 months after 3^rddose); may give 5^thdose at 4–6 yrs of age, unless 4^th dose was given after 4^thbirthday. Or, may be used to complete primary series and/or as booster doses in children who have received ≥1 DTwP doses; or concomitant other vaccines: see literature.

Adults

Not recommended.

Contraindications

Anaphylaxis associated with previous dose. Encephalopathy within 7 days after a previous DTaP or DTwP vaccination. Progressive neurologic disorders.

Precautions

Fever (≥105°F within 48 hours), persistent inconsolable crying (≥3 hours within 48 hours), shock (within 48 hours), convulsions (within 3 days), or Guillain-Barre syndrome (within 6 weeks) after previous DTaP or DTwP vaccine: see literature. Stable CNS disorders. Seizure risk (may give antipyretic; eg, acetaminophen). Acute illness. Bleeding disorders. Have epinephrine available. Immunodeficiency. Latex allergy. Pregnancy (Cat.C): not recommended.

Interactions

Concomitant vaccines: see literature. Immunosuppressants: may get suboptimal response.

Adverse Reactions

Local reactions, fever, irritability/fussiness, drowsiness, anorexia, vomiting, diarrhea, crying (≥1 hour).

How Supplied

Single-dose vials—10
Single-dose prefilled Tip-Lok syringe—5 (without needles)

Additional Resources

• Related Prescribing Note