Monograph Details
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Immune System
> Immunization
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DIPHTHERIA AND TETANUS TOXOIDS ADSORBED (for PEDIATRIC USE) |
| Manufacturer |
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Sanofi Pasteur, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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DT vaccine. |
| Generic Name |
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Tetanus and diphtheria toxoids; aluminum adsorbed; susp for IM inj; multi-dose vial preserved with thimerosal, single-dose vials contain trace amounts of thimerosal. |
| Indications |
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Tetanus and diphtheria immunization in patients 6 weeks to 7yrs of age when pertussis vaccine cannot be used. |
| Children |
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<6wks and ≥7yrs: not recommended. Give IM in anterolateral thigh or deltoid. 6wks–1yr: three 0.5mL doses 4–8 weeks apart, then 4th dose 6–12 months after third dose. 1–6yrs (up to 7yrs): two 0.5mL doses 4–8 weeks apart, then 3rd dose 6–12 months after the second dose (if >7yrs, use Td vaccine). Booster dose: see literature. |
| Contraindications |
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History of systemic allergic or neurologic reactions to a previous dose of DT. |
| Precautions |
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Defer in moderate or severe active respiratory or other febrile infection (may vaccinate if mild or minor illness) or during polio outbreak. Bleeding disorders. Immunosuppressed. Have epinephrine (1:1000) available. |
| Interactions |
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May get suboptimal response with immunosuppressants (eg, chemotherapy, high dose corticosteroids ≥2 weeks, radiation); consider deferring. |
| Adverse Reactions |
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Local reactions (eg, erythema, edema), malaise, fever, hypotension, arthralgia, nausea; rare: neurologic disorders. |
| How Supplied |
Single-dose vials—10
Multi-dose vial (5mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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