Monograph Details
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Hematology
> Thromboembolic disorders
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Heparin sodium |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Anticoagulant. |
| Generic Name |
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Heparin sodium 1000, 5000, 10000, 20000units; per mL; IV or SC inj. |
| Indications |
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Anticoagulation therapy. |
| Adults and Children |
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See literature. Individualize based on lab results and disease. |
| Contraindications |
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Severe thrombocytopenia. Uncontrollable active bleeding, except if due to DIC. When monitoring is not feasible. |
| Precautions |
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IM use not recommended. Bleeding or conditions with increased risk of bleeding. Monitor blood coagulation tests, platelet, hematocrit and occult blood in stool. Surgery. Bacterial endocarditis. Severe hypertension. White-clot syndrome. Heparin resistance. Women >60yrs of age. Not interchangeable (unit-for-unit) with low molecular weight heparins. Some formulations may contain benzyl alcohol; avoid in neonates. Pregnancy (Cat.C). |
| Interactions |
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Potentiated by anticoagulants, antiplatelets. Antagonized by digitalis, tetracyclines, nicotine, antihistamines. |
| Adverse Reactions |
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Bleeding, thrombocytopenia, local reactions, hypersensitivity reactions, increased aminotransferase levels. |
| How Supplied |
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Contact supplier. |
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