Monograph Details
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Hematology
> Thromboembolic disorders
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AGGRENOX |
| Manufacturer |
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Boehringer Ingelheim Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Combination antiplatelet. |
| Generic Name |
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Dipyridamole 200mg (ext-rel), aspirin 25mg (immediate-release); caps. |
| Indications |
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To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis. |
| Children |
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Not recommended. |
| Adults |
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Swallow whole. 1 cap twice daily. |
| Contraindications |
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NSAID allergy. Viral infection in children or teenagers. 3rd trimester pregnancy. |
| Precautions |
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History of asthma or peptic ulcer. Bleeding disorders. Severe coronary artery disease. Hypotension. Hepatic or renal insufficiency. Pregnancy (Cat.B for dipyridamole and Cat.D for aspirin). Nursing mothers. |
| Interactions |
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Increased risk of GI bleed with alcohol, NSAIDs. Potentiates anticoagulants, adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants. |
| Adverse Reactions |
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Headache, GI upset/bleed, somnolence, syncope, hemorrhage, blood disorders; rare: dizziness, flushing, hypotension, tinnitus, hyperglycemia, taste loss, increased liver enzymes. |
| How Supplied |
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Caps—60 |
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