Monograph Details
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Hematology
> Intermittent claudication
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PLETAL |
| Manufacturer |
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Otsuka America Pharmaceutical, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antiplatelet/vasodilator (PDE III inhibitor). |
| Generic Name |
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Cilostazol 50mg, 100mg; tabs. |
| Indications |
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Intermittent claudication. |
| Children |
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Not recommended. |
| Adults |
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100mg twice daily, ½ hr before or 2 hrs after breakfast and dinner. May reduce to 50mg twice daily if used with CYP3A4 or CYP2C19 inhibitors. |
| Contraindications |
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CHF of any severity. |
| Precautions |
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Severe underlying heart disease. Moderate to severe hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by drugs that inhibit CYP3A4 (eg, azole antifungals, macrolides, diltiazem, fluvoxamine, fluoxetine, nefazodone, sertraline) or CYP2C19 (eg, omeprazole). Avoid grapefruit juice. Cilostazol has been used with aspirin; caution with other antiplatelets, anticoagulants. |
| Adverse Reactions |
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Headache, diarrhea, abnormal stools, palpitations, peripheral edema, dizziness, tachycardia. |
| How Supplied |
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Tabs—60 |
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