Monograph Details
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Hematology
> Immune-mediated blood disorders
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WINRHO SDF |
| Manufacturer |
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Baxter |
| Legal Classification |
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Rx
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| Generic Name |
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Rho(D) immune globulin intravenous human 600IU (120micrograms), 1500IU (300micrograms), 2500IU (500micrograms), 5000IU (1000micrograms), 15000IU (3000micrograms); per vial; lyophilized pwd or soln; for IV or IM inj after reconstitution; preservative-free. |
| Indications |
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Suppression of Rh isoimmunization in nonsensitized Rho(D) negative women in appropriate obstetrical conditions, unless the fetus or father is known to be Rho(D) negative. Suppression of Rh isoimmunization in Rho(D) negative females after accidental transfusion of Rho(D) positive blood products. |
| Children |
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See literature. Do not give to infant for maternal Rh incompatability. |
| Adults |
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Pregnancy: 1500IU at 28 weeks gestation; if given early in pregnancy, repeat every 12 weeks. Post-delivery: 600IU as soon as possible (preferably within 72 hrs, up to 28 days) of an Rh incompatible delivery. Amniocentesis or other manipulation late in pregnancy (after 34 weeks gestation), abortion: 600IU as soon as possible (within 72 hrs). Chorionic villus sampling, amniocentesis (before 34 weeks gestation), threatened abortion: 1500IU as soon as possible, repeat every 12 weeks during pregnancy. Transfusion: IV route: 3000IU (600micrograms) every 8 hours; or IM route: 6000IU (1200micrograms) every 12 hours; for both: total dose based on exposure (see literature); give within 72 hours. |
| Contraindications |
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Rho(D) positive patients. IgA deficiency. Allergy to blood products. Treatment of immune globulin deficiency syndromes. |
| Precautions |
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Rho(D) negative patients who are Rh immunized. Thrombocytopenia. Pregnancy (Cat.C). |
| Interactions |
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Do not give live vaccines within 3 months. |
| Adverse Reactions |
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Local or infusion reactions, fever; see literature. |
| Extra Text |
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Note: Report all infections suspected to be transmitted by WinRho SDF to (800) 423-2090. |
| How Supplied |
Single-dose vials (pwd) 600IU, 1500IU, 5000IU—1 (w. diluent)
Single-dose vials (soln) 600IU, 1500IU, 2500IU, 5000IU, 15000IU—1 |
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