Monograph Details
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Hematology
> Bleeding disorders
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WINRHO SDF |
| Manufacturer |
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Baxter |
| Legal Classification |
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Rx
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| Generic Name |
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Rho(D) immune globulin intravenous human 600IU (120micrograms), 1500IU (300micrograms), 2500IU (500micrograms), 5000IU (1000micrograms), 15000IU (3000micrograms); per vial; lyophilized pwd or soln; for IV or IM inj after reconstitution; preservative-free. |
| Indications |
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Treatment of non-splenectomized, Rho(D) positive children with acute immune thrombocytopenic purpura (ITP); adults and children with chronic ITP and ITP secondary to HIV infection; in clinical situations requiring an increase in platelet count to prevent excessive hemorrhage. |
| Adults and Children |
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Give by IV inj only. Confirm Rho(D) positive prior to treatment. Initially: 250 IU/kg as single dose or 2 divided doses on separate days; if Hgb <10g/dL, reduce to 125–200 IU/kg. Maintenance: 125–300 IU/kg; Hbg >10g/dL: 250–300 IU/kg; Hgb 8–10g/dL: 125–200 IU/kg; Hgb <8g/dL: use with caution. Base frequency and dose on clinical response. |
| Contraindications |
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IgA deficiency. Allergy to blood products. Treatment of immune globulin deficiency syndromes. |
| Precautions |
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Not for use in Rho(D) negative or splenectomized patients; monitor for intravascular hemolysis, anemia, renal insufficiency; hemoglobin <10g/dL decrease dose, if <8g/dL use extreme caution. Pregnancy (Cat.C). |
| Interactions |
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Do not give live vaccines within 3 months. |
| Adverse Reactions |
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Headache, chills, fever, local or infusion reactions; see literature. |
| Extra Text |
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Note: Report all infections suspected to be transmitted by WinRho SDF to (800) 423-2090. |
| How Supplied |
Single-dose vials (pwd) 600IU, 1500IU, 5000IU—1 (w. diluent)
Single-dose vials (soln) 600IU, 1500IU, 2500IU, 5000IU, 15000IU—1 |
| Additional Resources |
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• Related Prescribing Note |
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