Monograph Details
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Hematology
> Bleeding disorders
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RECOTHROM |
| Manufacturer |
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ZymoGenetics, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Topical hemostatic. |
| Generic Name |
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Thrombin [recombinant] 5000 IU, 20000 IU; per vial; pwd for topical use after reconstitution; preservative-free. |
| Indications |
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Aid to hemostasis for minor bleeding/oozing from capillaries and venules when standard surgical techniques are inadequate or ineffective. May use with absorbable gelatin sponge. |
| Children |
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Not recommended. |
| Adults |
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Apply directly to bleeding area, or soak into absorbable gelatin sponge and apply in a single layer. |
| Contraindications |
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Not for direct injection into circulatory system. Not for treatment of massive or brisk arterial bleeding. Hypersensitivity to hamster proteins. |
| Precautions |
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Avoid systemic absorption (thrombosis may occur). Hypersensitivity to snake proteins. Pregnancy (Cat.C). |
| Adverse Reactions |
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Incision site complication, infection, pain, bleeding, nausea/vomiting, cardiac events, thromboembolic events. |
| How Supplied |
Single-use vial (5000 IU, 20000 IU)—1 (w. diluent, supplies)
20000 IU Recothrom kit (co-packaged with ZymoGenetics Spray Applicator Kit)—1 |
| Additional Resources |
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• Related Prescribing Note |
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