Monograph Details
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Hematology
> Bleeding disorders
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AMICAR TABLETS |
| Manufacturer |
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Xanodyne Pharmacal, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Hemostatic (plasmin and plasminogen activator inhibitor). |
| Generic Name |
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Aminocaproic acid 500mg, 1000mg; scored tabs. |
| Also |
• AMICAR INJECTION
• AMICAR ORAL SOLUTION
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| Indications |
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Bleeding associated with fibrinolysis. |
| Children |
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Not recommended. |
| Adults |
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Initially 5g during 1st hour, then 1g/hour for 8 hours or until bleeding is controlled. |
| Contraindications |
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Active intravascular clotting process. Disseminated intravascular coagulation without concomitant heparin. |
| Precautions |
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Upper urinary tract bleeding: not recommended. Cardiac, hepatic or renal disease. Risk of myopathy with long-term use; monitor creatine phosphokinase (CPK); discontinue if CPK rises. Avoid rapid IV administration. Neonates. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Avoid concomitant Factor IX complex or Anti-inhibitor Coagulant concentrates; may increase thrombosis risk. |
| Adverse Reactions |
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Inj site reactions, bradycardia, hypotension, GI upset, edema, headache, malaise, CNS effects, thrombosis, others; rare: myopathy. |
| How Supplied |
Tabs—100
Oral soln—473mL
Vials (20mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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