Monograph Details
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Hematology
> Anemias
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VENOFER |
| Manufacturer |
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American Regent, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Hematinic. |
| Generic Name |
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Iron (as sucrose) 20mg/mL; soln for IV inj or infusion; preservative-free. |
| Indications |
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Iron deficiency anemia in chronic kidney disease. |
| Children |
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Not recommended. |
| Adults |
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Give by slow IV inj (undiluted) or infusion (diluted). Usual total cumulative dose: 1000mg. Hemodialysis dependent: 100mg slow IV inj over 2–5 minutes or infuse 100mg over at least 15 minutes per consecutive session. Non-dialysis dependent: 200mg slow IV inj over 2–5 minutes on 5 different occasions within a 14-day period; limited experience with IV infusion (see literature). Peritoneal dialysis dependent: Two infusions of 300mg over 1.5 hours 14 days apart, then one 400mg infusion over 2.5 hours 14 days later. |
| Contraindications |
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Anemia not caused by iron deficiency. Iron overload. |
| Precautions |
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Withhold therapy if tissue iron overload suspected. Monitor hemoglobin, hematocrit, serum ferritin, transferrin saturation; obtain serum iron values 48 hours after dosing. Pregnancy (Cat. B). Nursing mothers. |
| Interactions |
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May reduce absorption of concomitant oral iron preparations. |
| Adverse Reactions |
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Hypotension (esp. by IV infusion), hypertension, muscle cramps, GI upset, headache, dizziness, chest pain, graft complications, dysgeusia, pruritus, edema, constipation; rare: hypersensitivity reactions (may be severe). |
| How Supplied |
Single-dose vials (100mg/5mL)—1, 10, 25
200mg/10mL—1, 5,10 |
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