Monograph Details
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Hematology
> Anemias
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DEXFERRUM |
| Manufacturer |
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American Regent, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Hematinic. |
| Generic Name |
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Iron (as dextran complex) 50mg/mL; soln for IV inj. |
| Indications |
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Iron deficiency where oral therapy is unsatisfactory or impossible. |
| Adults and Children |
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<4months: not recommended. Give by IV inj. Administer 0.5mL test dose first. ≥4months: Iron deficiency anemia: determine total dose based on hemoglobin and body weight (see literature). Iron replacement for blood loss: Replacement iron (in mg) = blood loss (in mL) X hematocrit. Max daily doses: <5kg: 0.5mL (25mg), <10kg: 1mL (50mg), ≥10kg: 2mL (100mg). |
| Contraindications |
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Anemia not associated with iron deficiency. |
| Precautions |
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Hepatic impairment. Avoid during acute phase of infectious kidney disease. Cardiovascular disease. Avoid large IV doses: higher incidence of adverse events. Have epinephrine available. History of allergies, asthma. Iron overload more likely with hemoglobinopathies or refractory anemias. Rheumatoid arthritis. Neonates. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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May falsely elevate serum bilirubin and decrease serum calcium. |
| Adverse Reactions |
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See literature. Anaphylactic reactions (may be fatal), cardiovascular events, pruritus, GI upset, arthralgia, arthritis, inj site reactions, others. |
| How Supplied |
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Single-dose vials (1mL, 2mL)—1, 10 |
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