Monograph Details
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Gastrointestinal Tract
> Nausea
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ZOFRAN INJECTION |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Selective 5-HT3 receptor antagonist. |
| Generic Name |
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Ondansetron (as HCl dihydrate) 2mg/mL; IV or IM inj. |
| Also |
• ZOFRAN
• ZOFRAN INJECTION PREMIXED
• ZOFRAN ODT
• ZOFRAN ORAL SOLUTION
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| Indications |
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Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. Prevention of post-op nausea and vomiting. |
| Children |
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Chemotherapy (vials must be diluted; see literature): Infuse over 15 minutes. <6 months: see literature. 6 months–18 yrs: 0.15mg/kg IV for 3 doses every 4 hours beginning 30 minutes before chemotherapy. Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2–5 minutes: <1 month: see literature. 1 month–12 yrs (<40kg): 0.1mg/kg. ≥40kg: 4mg. Give IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs. |
| Adults |
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Chemotherapy (vials must be diluted; see literature): >18 yrs: Infuse over 15 minutes, 32mg IV for 1 dose beginning 30 minutes before chemotherapy. Or, 0.15mg/kg IV every 4 hours for 3 doses beginning 30 minutes before chemotherapy. Severe hepatic dysfunction: max 8mg/day. Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2–5 minutes: 4mg IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs. Or, may use 4mg IM undiluted as a single injection. |
| Precautions |
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<4 months of age (monitor closely). May mask progressive ileus and/or gastric distention. Hepatic dysfunction. Pregnancy (Cat.B). Nursing mothers. |
| Adverse Reactions |
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Diarrhea, headache, fever, constipation, abdominal pain, weakness, rash, transient blindness; rare: angina, bronchospasm, anaphylaxis, seizures, ECG changes (including QT prolongation). |
| How Supplied |
Tabs 4mg, 8mg—30
ODT 4mg—30
ODT 8mg—10, 30
Oral soln—50mL
Premixed (32mg/50mL)—6
Single-dose vial (2mg/mL)—5 (2mL/vial)
Multidose vial (2mg/mL)—1 (20mL/vial) |
| Additional Resources |
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• Related Prescribing Note |
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