Monograph Details
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Gastrointestinal Tract
> Nausea
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THORAZINE |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Phenothiazine. |
| Generic Name |
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Chlorpromazine HCl 10mg, 25mg, 50mg, 100mg, 200mg; tabs; contains parabens. |
| Also |
• THORAZINE INJ
• THORAZINE SUPPOSITORIES
• THORAZINE SYRUP
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| Indications |
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Nausea and vomiting. |
| Children |
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<6months: not recommended. ≥6months: Oral: 0.25mg/lb every 4–6 hrs. Rectal: 0.5mg/lb every 6–8 hrs as needed. |
| Adults |
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Oral: 10–25mg every 4–6 hrs as needed. Rectal: 50–100mg every 6–8 hrs as needed. |
| Contraindications |
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Coma. CNS or bone marrow depression. Reye's syndrome. |
| Precautions |
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Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects. |
| Adverse Reactions |
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Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome. |
| How Supplied |
Tabs—100
Syrup—4oz
Supp—12
Amp (1mL, 2mL)—10
Vial (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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