Monograph Details
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Gastrointestinal Tract
> Nausea
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Prochlorperazine |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Piperazine phenothiazine. |
| Generic Name |
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Prochlorperazine (as maleate) 5mg, 10mg; tabs. |
| Also |
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• Prochlorperazine Suppositories
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| Indications |
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Severe nausea and vomiting. |
| Children |
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<2yrs or <20lbs: not recommended. Oral: 20–29lbs: 2½mg once or twice daily; max 7.5mg/day. 30–39lbs: 2½mg 2–3 times daily; max 10mg/day. 40–85lbs: 2½mg 3 times daily or 5mg twice daily; max 15mg/day. |
| Adults |
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Oral: 5–10mg 3–4 times daily; usual max 40mg/day. Rectal: 25mg twice daily. |
| Contraindications |
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Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs. |
| Precautions |
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Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write Rx using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test. |
| Adverse Reactions |
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Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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