Monograph Details
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Gastrointestinal Tract
> Nausea
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PHENERGAN RECTAL SUPPOSITORIES |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Phenothiazine. |
| Generic Name |
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Promethazine HCl 12.5mg, 25mg, 50mg. |
| Also |
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• PHENERGAN
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| Indications |
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Motion sickness. Perioperative nausea & vomiting. |
| Children |
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<2 years: see Contraindications. Motion sickness: ≥2 years: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6 hour intervals. |
| Adults |
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Motion sickness: 25mg 30–60 minutes before travel; may repeat in 8–12 hours; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6 hour intervals. |
| Contraindications |
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Children <2 years. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children. |
| Precautions |
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Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2 years. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results. |
| Adverse Reactions |
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Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal). |
| How Supplied |
Tabs—100
Supp—12 |
| Additional Resources |
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• Related Prescribing Note |
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