Monograph Details
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Gastrointestinal Tract
> Nausea
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GRANISOL |
| Manufacturer |
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Hawthorn Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Selective 5-HT3 receptor antagonist. |
| Generic Name |
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Granisetron (as HCl) 1mg/5mL; soln; orange-flavor. |
| Indications |
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Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin) or with radiation (including total body irradiation and fractionated abdominal radiation). |
| Children |
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Not recommended. |
| Adults |
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Chemotherapy: give only on the days chemo is given. 2mg once daily up to 1 hour before chemo; or, 1mg up to 1 hour before chemo, then 1mg 12 hours after 1st dose. Radiation: 2mg once daily within 1 hour of radiation. |
| Precautions |
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Abdominal surgery. May mask progressive ileus and/or gastric distention. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with drugs that affect CYP450. |
| Adverse Reactions |
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Headache, asthenia, diarrhea, constipation, abdominal pain. |
| How Supplied |
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Soln—30mL |
| Additional Resources |
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• Related Prescribing Note |
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