Monograph Details
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Gastrointestinal Tract
> Nausea
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ANZEMET INJECTION |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Selective 5-HT3 receptor antagonist. |
| Generic Name |
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Dolasetron mesylate 20mg/mL; IV inj. |
| Also |
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• ANZEMET
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| Indications |
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Prevention of nausea & vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses. Prevention of post-op nausea & vomiting. Treatment of post-op nausea +/or vomiting (IV only). |
| Children |
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May give by IV inj as in adult dose, or may be diluted in apple or apple-grape juice and taken orally (timing and doses are different; see literature). <2 yrs: not recommended. 2–16 yrs: Chemotherapy-induced: 1.8mg/kg IV (max 100mg) about 30 minutes before chemotherapy; or, 1.8mg/kg (max 100mg) diluted in juice and taken orally within 1 hour before chemotherapy. Prevention: 0.35mg/kg IV (max 12.5mg) about 15 minutes before stopping anesthesia; or, 1.2mg/kg (max 100mg) diluted in apple or apple-grape juice and taken orally within 2 hrs before surgery. Treatment: 0.35mg/kg IV as soon as needed. |
| Adults |
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Give by IV inj, either undiluted 100mg over 30 seconds or diluted to 50mL and infused over up to 15 minutes. ≥16yrs: Chemotherapy-induced: 1.8mg/kg about 30 minutes before chemotherapy; or, may give 100mg IV. Prevention: 12.5mg about 15 minutes before stopping anesthesia. Treatment: 12.5mg as soon as needed. |
| Precautions |
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Patients at risk of developing prolongation of cardiac conduction intervals, especially QTc (e.g., congenital QT syndrome, hypokalemia, hypomagnesemia); see Interactions. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with drugs which can prolong ECG intervals (esp. QTc) and with cumulative high-dose anthracycline therapy. |
| Adverse Reactions |
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Headache, dizziness, pain, fatigue, diarrhea, tachycardia, ECG changes. |
| How Supplied |
Tabs—5
Single-use vials (100mg/5mL)—1
Single-use ampules (12.5mg/0.625mL)—6
Prefilled Carpuject cartridges (12.5mg/0.625mL)—10
Multidose vial (500mg/25mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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