Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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ZEGERID for ORAL SUSPENSION |
| Manufacturer |
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Santarus, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Acid pump inhibitor. |
| Generic Name |
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Omeprazole 20mg, 40mg; per packet; pwd; contains 460mg Na+/packet (as sodium bicarbonate). |
| Also |
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• ZEGERID CAPSULES
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| Indications |
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Short-term treatment of active benign gastric ulcer, active duodenal ulcer, erosive esophagitis (EE). Symptomatic GERD. Maintenance of healing of EE. To reduce risk of upper GI bleed in critically ill patients (40mg oral susp only). |
| Children |
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<18yrs: not recommended. |
| Adults |
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Take on empty stomach. Caps: swallow whole with water only. Susp: mix in 15–30mL water only; drink immediately; refill cup with water and drink; or, may give via NG/OG tube (see literature). Due to sodium bicarbonate component, two 20mg packets or caps are not equivalent to one 40mg packet or cap. ≥18yrs: Active duodenal ulcer: 20mg once daily for 4 weeks; may continue 4 more weeks. Gastric ulcer: 40mg once daily for 4–8 weeks. GERD (no esophageal lesions): 20mg once daily for up to 4 weeks. EE with GERD symptoms: 20mg once daily for 4–8 weeks. Maintenance of healing of EE: 20mg once daily. GI bleed risk reduction: day 1: initially 40mg susp once then 40mg susp 6–8 hours later, then 40mg susp once daily for up to 14 days. Hepatic impairment or Asian: consider reduced dose. |
| Contraindications |
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Metabolic alkalosis. Hypocalcemia. |
| Precautions |
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Bartter's syndrome. Sodium-restricted diets. Hypokalemia. Respiratory alkalosis. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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May potentiate diazepam, phenytoin, warfarin, tacrolimus, clarithromycin. May alter absorption of pH-dependent drugs (eg, ketoconazole, ampicillin, iron). May antagonize atazanavir. Monitor drugs metabolized by CYP450 (eg, cyclosporine, disulfiram, benzodiazepines). May give antacids concomitantly. Long-term use with calcium or milk may cause milk-alkali syndrome. |
| Adverse Reactions |
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Headache, abdominal pain, dizziness, GI effects, rash, constipation, cough, back pain. |
| How Supplied |
Caps—30
Susp—30 packets/box |
| Additional Resources |
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• Related Prescribing Note |
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