Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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ZANTAC INJECTION PREMIXED |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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H2 blocker. |
| Generic Name |
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Ranitidine (as HCl) 1mg/mL in sodium chloride 0.45%; IV infusion; preservative-free. |
| Also |
• ZANTAC
• ZANTAC EFFERDOSE
• ZANTAC INJECTION
• ZANTAC SYRUP
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| Indications |
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Hospitalized patients with pathological hypersecretory conditions, intractable duodenal ulcer. Short-term alternative to oral therapy. |
| Children |
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<1month: not recommended. ≥1month–16yrs: Treatment of duodenal ulcer: 2–4mg/kg per day in divided doses every 6–8hrs; max 50mg every 6–8hrs. |
| Adults |
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For slow IV drip only. >16yrs: Intermittent infusion: 50mg every 6–8hrs (infuse over 15–20min); usual max 400mg/day. Continuous IV infusion, or for Zollinger-Ellison: see literature. Renal impairment (CrCl<50mL/min): 50mg every 18–24hrs or more often if needed (intermittent only). Coincide a dose for end of hemodialysis. |
| Precautions |
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History of acute porphyria: not recommended. Renal impairment: reduce dose. Hepatic dysfunction. Discontinue if hepatic disorders occur. Monitor SGPT if on high-dose IV therapy for ≥5 days. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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May increase triazolam, midazolam, glipizide, procainamide levels. May decrease ketoconazole, atazanavir, delaviridine, gefitnib levels. Monitor anticoagulants. May cause false (+) urine protein test with Multistix. |
| Adverse Reactions |
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Headache, GI disturbances, jaundice, hepatitis, rash; rare: CNS disturbances, arrhythmias, blurred vision, arthralgia, myalgia, inj site reactions, blood dyscrasias, anaphylaxis, angioneurotic edema, acute interstitial nephritis, bradycardia with rapid administration (IV); increased risk of pneumonia (see literature). |
| How Supplied |
Tabs 150mg—60, 180, 500
300mg—30
EFFERdose tabs—60
Syrup—pt
Inj single dose 2mL—10
Multidose 6mL—1
Premixed 50mL—24 |
| Additional Resources |
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• Related Prescribing Note |
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