Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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TAGAMET |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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H2 blocker. |
| Generic Name |
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Cimetidine 300mg, 400mg; tabs. |
| Indications |
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Active duodenal or benign gastric ulcer. Maintenance of healed duodenal ulcers. Pathological hypersecretory conditions (e.g. Zollinger-Ellison syndrome). GERD. |
| Children |
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<16 yrs: not recommended; see literature. Doses of 20–40mg/kg per day have been used. |
| Adults |
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Active duodenal ulcer: 800mg at bedtime for 4–8 wks. Maintenance: 400mg at bedtime. Active benign gastric ulcer: 800mg at bedtime or 300mg 4 times daily with meals and at bedtime for 6 wks. Hypersecretory conditions: 300mg 4 times daily with meals and at bedtime; max 2.4g/day. GERD: 800mg 2 times daily or 400mg 4 times daily for max 12 weeks; see literature. For difficult to heal ulcers: see literature. |
| Precautions |
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Impaired renal or hepatic function. Elderly. Debilitated. Immunocompromised. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid antacids within 1 hour of dosing. May potentiate anticoagulants, phenytoin, theophylline, lidocaine, and others (see literature) by inhibition of hepatic microsomal enzymes. May alter absorption of drugs affected by gastric pH (e.g., ketoconazole), give 2 hours before cimetidine. |
| Adverse Reactions |
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Headache, diarrhea, dizziness, somnolence, CNS disturbances, gynecomastia, rash (maybe serious eg, Stevens-Johnson syndrome); rare: arthralgia, myalgia, blood dyscrasias, nephritis, increased serum transaminases, pancreatitis, bradycardia, tachycardia; increased risk of community-acquired pneumonia (see literature). |
| How Supplied |
Tabs 300mg—100
400mg—60 |
| Additional Resources |
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• Related Prescribing Note |
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