Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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REGLAN |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Prokinetic. |
| Generic Name |
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Metoclopramide (as HCl) 5mg, +10mg; +scored tabs. |
| Indications |
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Symptomatic refractory GERD. |
| Children |
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Not recommended. |
| Adults |
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5–15mg 4 times daily 30 minutes before meals and at bedtime. Intermittent symptoms, up to 20mg prior to provoking situation; max 12 weeks per therapeutic course. Renal impairment: reduce dose. |
| Contraindications |
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When stimulation of GI motility may be dangerous (eg, obstruction, perforation, or hemorrhage). Pheochromocytoma. Epilepsy. Concomitant drugs which may cause extrapyramidal reactions (eg, phenothiazines, haloperidol). |
| Precautions |
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Parkinsonism. Tardive dyskinesia. History of breast cancer or depression. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Hypertensive crisis with MAOIs. Additive sedation with alcohol, other CNS depressants. Antagonized by anticholinergics and narcotics. Monitor insulin use; may diminish gastric and accelerate intestinal absorption of drugs or food. |
| Adverse Reactions |
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Restlessness, drowsiness, fatigue, extrapyramidal effects, parkinsonism, tardive dyskinesia, neuroleptic malignant syndrome, dizziness, endocrine disturbances, hypo- or hypertension, GI upset. |
| How Supplied |
Tabs 5mg—100
10mg—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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