Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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PROTONIX TABLETS |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Acid pump inhibitor. |
| Generic Name |
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Pantoprazole (as sodium) 20mg, 40mg; e-c delayed-release tabs. |
| Also |
• PROTONIX for ORAL SUSP
• PROTONIX I.V.
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| Indications |
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Short-term treatment and maintenance of healing of erosive esophagitis (EE), symptomatic GERD. Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome). |
| Children |
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Not recommended. |
| Adults |
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Take 30mins before a meal. Swallow whole. Do not crush or chew granules. Susp: Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). Treatment of EE: 40mg once daily for ≤8 weeks; if not healed, may repeat for 8 more weeks. Maintenance of EE healing: 40mg once daily. Pathological hypersecretory conditions: initially 40mg twice daily; max 240mg/day. |
| Precautions |
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Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron, ampicillin). May antagonize atazanavir. Monitor warfarin. May give antacids concomitantly. IV form chelates metal ions. May cause false (+) urine THC test. |
| Adverse Reactions |
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Headache, diarrhea, rash, hyperglycemia, dizziness, pruritus, inj site reactions; rare: cyanocobalamin deficiency. |
| How Supplied |
Tabs—90
Susp—30 packets/box
Vials (40mg)—1 |
| Additional Resources |
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• Related Prescribing Note |
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