Monograph Details
|
|
Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
|
|
PROTONIX for ORAL SUSP |
| Manufacturer |
|
Wyeth Pharmaceuticals |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Acid pump inhibitor. |
| Generic Name |
|
Pantoprazole (as sodium) 40mg; per packet; e-c delayed-release granules. |
| Also |
• PROTONIX I.V.
• PROTONIX TABLETS
|
| Indications |
|
Short-term treatment and maintenance of healing of erosive esophagitis (EE), symptomatic GERD. Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome). |
| Children |
|
Not recommended. |
| Adults |
|
Take 30mins before a meal. Swallow whole. Do not crush or chew granules. Susp: Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). Treatment of EE: 40mg once daily for ≤8 weeks; if not healed, may repeat for 8 more weeks. Maintenance of EE healing: 40mg once daily. Pathological hypersecretory conditions: initially 40mg twice daily; max 240mg/day. |
| Precautions |
|
Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
|
May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron, ampicillin). May antagonize atazanavir. Monitor warfarin. May give antacids concomitantly. IV form chelates metal ions. May cause false (+) urine THC test. |
| Adverse Reactions |
|
Headache, diarrhea, rash, hyperglycemia, dizziness, pruritus, inj site reactions; rare: cyanocobalamin deficiency. |
| How Supplied |
Tabs—90
Susp—30 packets/box
Vials (40mg)—1 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
