Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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NEXIUM IV |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Acid pump inhibitor. |
| Generic Name |
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Esomeprazole (as sodium) 20mg, 40mg; per vial; pwd for IV inj after reconstitution or for infusion after reconstitution and dilution. |
| Also |
• NEXIUM
• NEXIUM for ORAL SUSPENSION
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| Indications |
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Short-term (up to 10 days) alternative to oral therapy for GERD with erosive esophagitis. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Inject IV over ≥ 3 minutes or infuse IV over 10–30 minutes. ≥18yrs: 20–40mg once daily for ≤10 days; switch to oral form when feasible. Severe hepatic impairment: max 20mg/day. |
| Precautions |
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Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron salts, digoxin). May affect drugs metabolized by CYP2C19. May antagonize atazanavir. Monitor warfarin. May give antacids concomitantly. |
| Adverse Reactions |
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Headache, diarrhea, abdominal pain, nausea, flatulence, constipation, dry mouth, inj site reactions; rare: rash, allergic reactions. |
| Extra Text |
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Note: See Biaxin for more information on clarithromycin. See Trimox or Amoxil for more information on amoxicillin. |
| How Supplied |
Caps—30, 90, 1000
Susp—30 packets/box
IV soln (single-use vial)—10 |
| Additional Resources |
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• Related Prescribing Note |
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