Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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CYTOTEC |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Prostaglandin E1 analogue. |
| Generic Name |
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Misoprostol 100 micrograms, 200 micrograms; tabs. |
| Indications |
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Prevention of NSAID-induced gastric ulcers. |
| Children |
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Not recommended. |
| Adults |
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Take with food. 200 micrograms 4 times daily with meals and at bedtime. May reduce dose if not tolerated. |
| Contraindications |
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Pregnancy (Cat.X). |
| Precautions |
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For women of childbearing potential: negative serum pregnancy test within 2 weeks before starting therapy; begin on 2nd or 3rd day of next menstrual period; maintain contraception during therapy; give oral and written warnings on risks in pregnancy. Inflammatory bowel disease. Conditions rendering dehydration dangerous. Nursing mothers: not recommended. |
| Interactions |
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Avoid magnesium-containing antacids (to reduce diarrhea risk). |
| Adverse Reactions |
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Diarrhea, abdominal pain, headache, gynecological effects (eg, spotting, cramps), abortion, premature birth, birth defects, uterine rupture. |
| How Supplied |
Tabs 100 mcg—60, 120
200 mcg—60, 100 |
| Additional Resources |
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• Related Prescribing Note |
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