Monograph Details
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Gastrointestinal Tract
> Hyperacidity, GERD, and ulcers
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ACIPHEX |
| Manufacturer |
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Eisai Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Acid pump inhibitor. |
| Generic Name |
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Rabeprazole sodium 20mg; delayed-release, e-c tabs. |
| Indications |
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Triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment of erosive or ulcerative gastroesophageal reflux disease (GERD), GERD symptoms, or duodenal ulcers. Maintenance of healing and reduction in relapse rates of heartburn symptoms in erosive or ulcerative GERD. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome). |
| Children |
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<18 years: not recommended. |
| Adults |
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Swallow whole. ≥18 years: Triple therapy: rabeprazole 20mg + amoxicillin 1g + clarithromycin 500mg, all twice daily (w. AM and PM meals) for 7 days. GERD healing: 20mg once daily for 4–8 weeks; may repeat for 8 more weeks. GERD symptoms: 20mg once daily for 4–8 weeks. GERD maintenance: 20mg once daily. Duodenal ulcer healing: 20mg once daily after breakfast for up to 4 weeks. Hypersecretory conditions: initially 60mg once daily; titrate; doses up to 100mg once daily or 60mg twice daily have been used. |
| Precautions |
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Severe hepatic impairment. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, digoxin). May give antacids concomitantly. Monitor warfarin. |
| Adverse Reactions |
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Headache. |
| Extra Text |
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Note: See Amoxil or Trimox entry for more information on amoxicillin. See Biaxin entry for more information on clarithromycin. |
| How Supplied |
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Tabs—30, 90 |
| Additional Resources |
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• Related Prescribing Note |
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