Monograph Details
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Gastrointestinal Tract
> Diarrhea
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LOMOTIL LIQUID |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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CV |
| Pharmacological Class |
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Opioid + anticholinergic. |
| Generic Name |
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Diphenoxylate HCl 2.5mg, atropine sulfate 0.025mg; per 5mL liq; alcohol 15%. |
| Also |
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• LOMOTIL
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| Indications |
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Adjunct to fluid and electrolyte replacement in diarrhea. |
| Children |
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<2 yrs: not recommended. 2–12 yrs: initially 0.3–0.4mg/kg in 4 divided doses until diarrhea is controlled. Maintenance: 25% initial dose; max 48hrs. |
| Adults |
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2 tabs or 10mL 4 times daily until diarrhea is controlled. Maintenance: 2 tabs or 10mL daily. |
| Contraindications |
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Pseudomembranous enterocolitis. Obstructive jaundice. Diarrhea caused by organisms that penetrate intestinal mucosa. Age <2 yrs. |
| Precautions |
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Dehydration. Acute ulcerative colitis; discontinue if toxic megacolon occurs. Hepatic or renal disease. Abnormal liver function tests. Drug abusers. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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MAOIs may cause hypertensive crisis. Antimuscarinics may cause paralytic ileus. Potentiates sedation with alcohol, CNS depressants. May delay elimination of other drugs metabolized by CYP450. |
| Adverse Reactions |
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Nausea, vomiting, abdominal discomfort, paralytic ileus, toxic megacolon, dizziness, drowsiness, headache, euphoria, tachycardia, numbness of extremities, pruritus, urticaria, angioneurotic edema, anticholinergic effects; respiratory depression (overdosage), atropinism. |
| How Supplied |
Tabs—100, 500, 1000, 2500
Liq—2oz (w. dropper) |
| Additional Resources |
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• Related Prescribing Note |
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