Monograph Details
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Eye Disorders
> Glaucoma
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ISTALOL |
| Manufacturer |
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ISTA Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Noncardioselective β-blocker. |
| Generic Name |
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Timolol (as maleate) 0.5%; oph soln; contains benzalkonium chloride. |
| Indications |
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Open-angle glaucoma. Ocular hypertension. |
| Children |
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Not recommended. |
| Adults |
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1 drop in affected eye(s) once daily in the AM. |
| Contraindications |
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Greater than 1st degree AV block. Overt cardiac failure. Cardiogenic shock. Sinus bradycardia. Bronchial asthma. Severe COPD. History of bronchospasm. Not for use as a sole agent in angle-closure glaucoma. |
| Precautions |
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History of cardiac failure. Discontinue at 1st sign of cardiac failure, and before surgery. Avoid abrupt cessation. Diabetes. May mask hypoglycemia, thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Contact lenses (remove; may reinsert 15 min after instillation). Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid other topical β-blockers. May potentiate systemic β-blockers, reserpine, hypoglycemics, and mydriatic effect of topical epinephrine. May be potentiated by quinidine. May cause conduction defects with digoxin, calcium channel blockers (avoid concomitant use in impaired cardiac function). |
| Adverse Reactions |
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Local irritation (burning, stinging), blurred vision, cataract, conjunctival injection, infection, headache, hypertension, itching. Systemic β-blocker effects (eg, bronchospasm, bradycardia, cardiac failure, muscle weakness). |
| How Supplied |
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Soln—5mL |
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