Monograph Details
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Eye Disorders
> Glaucoma
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IOPIDINE |
| Manufacturer |
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Alcon Laboratories, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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α2-agonist. |
| Generic Name |
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Apraclonidine (as HCl) 0.5%; oph. soln; contains benzalkonium chloride. |
| Indications |
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Short-term adjunctive therapy to reduce elevated IOP. |
| Children |
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Not recommended. |
| Adults |
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1–2 drops 3 times daily. Allow at least 5min between instillation of other oph drugs. |
| Contraindications |
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Clonidine allergy. Concomitant MAOIs. |
| Precautions |
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Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's syndrome. Thromboangiitis obliterans. Renal or hepatic impairment. Depression. Masks hypoglycemia. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Hypertensive crisis with MAOIs. May potentiate CNS depressants, alcohol. May be antagonized by tricyclic antidepressants. Additive hypotensive effects with neuroleptics; hypotensive and pulse effects with β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). |
| Adverse Reactions |
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Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching, headache, asthenia, dry nose, taste perversion; tachyphylaxis may develop after 1 month. |
| How Supplied |
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Soln—5mL, 10mL |
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