Monograph Details
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Endocrine System
> Thyroid disease
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Propylthiouracil |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antithyroid. |
| Generic Name |
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Propylthiouracil 50mg; scored tabs; contains docusate sodium. |
| Indications |
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Hyperthyroidism. |
| Children |
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Give in 3 equally divided doses every 8 hrs. <6yrs: not recommended. 6–10yrs: initially 50–150mg/day. ≥10yrs: initially 150–300mg/day. |
| Adults |
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Give in 3 equally divided doses every 8 hrs. Initially 300mg/day. Severe conditions: initially 400mg/day; max 900mg/day. Maintenance: 100–150mg/day. |
| Contraindications |
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Nursing mothers. |
| Precautions |
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Monitor blood. Discontinue if hepatic dysfunction, agranulocytosis, aplastic anemia, fever, or exfoliative dermatitis occurs. Pregnancy (Cat.D). |
| Interactions |
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May potentiate anticoagulants. Caution with other drugs that may cause agranulocytosis. |
| Adverse Reactions |
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Rash, urticaria, GI upset, arthralgia, paresthesia, taste loss/perversion, hair loss, myalgia, headache, drowsiness, edema, vertigo, jaundice, blood dycrasias, lupus-like syndrome, drug fever, hepatitis, hypoprothrombinemia. |
| How Supplied |
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Tabs—100, 1000 |
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