Monograph Details
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Endocrine System
> Thyroid disease
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CYTOMEL |
| Manufacturer |
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King Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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T3 (synthetic). |
| Generic Name |
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Liothyronine sodium 5micrograms, 25micrograms, 50micrograms; tabs. |
| Indications |
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Hypothyroidism. |
| Children |
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Initially 5micrograms daily; may increase by 5micrograms daily every 3–4 days. Cretinism: maintenance dose: <1yr: 20micrograms/day. 1–3 yrs: 50micrograms/day. >3yrs: as adult. |
| Adults |
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Hypothyroidism: initially 25micrograms daily; may increase by up to 25micrograms every 1–2 weeks; usual maintenance 25–75micrograms daily. Myxedema, simple goiter: initially 5micrograms daily; may increase by 5–10micrograms daily every 1–2 weeks to 25micrograms daily, then may increase by 5–25micrograms every 1–2 weeks (myxedema) or by 12.5 or 25micrograms daily every 1–2 weeks (simple goiter). Maintenance: myxedema: 50–100micrograms/day; simple goiter: 75micrograms/day. |
| Elderly |
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Initially 5micrograms daily; may increase by 5micrograms every 1–2 weeks. |
| Contraindications |
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Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. |
| Precautions |
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Not for treatment of obesity. Cardiovascular disease, angina, elderly: use lower initial dose. Adrenocortical insufficiency. Monitor for craniosynostosis in infants. Pregnancy (Cat.A). Nursing mothers. |
| Interactions |
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Monitor oral anticoagulants, hypoglycemics, digoxin. Estrogens affect thyroid function tests. Monitor for hypertension with ketamine. Toxicity with larger doses of sympathomimetics (e.g., anorectics). |
| Adverse Reactions |
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Hyperthyroidism, transient hair loss in children. |
| How Supplied |
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Tabs—100 |
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