Monograph Details
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Endocrine System
> Pituitary disorders
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SEROSTIM |
| Manufacturer |
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EMD Serono, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Growth hormone (GH). |
| Generic Name |
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Somatropin (rDNA origin) 4mg, 5mg, 6mg; per vial; for SC inj after reconstitution. |
| Indications |
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AIDS wasting or cachexia. |
| Children |
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Not recommended; see literature. 6–17yrs: doses of 0.04mg/kg or 0.07mg/kg per day have been used. |
| Adults |
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Give by SC inj once daily at bedtime. Rotate inj site. <35kg: 0.1mg/kg. 35–45kg: 4mg. 45–55kg: 5mg. >55kg: 6mg. Risk factors for adverse effects (eg, glucose intolerance): initially 0.1mg/kg every other day. |
| Precautions |
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Use only under guidance of a physician trained in AIDS management. Reevaluate if weight loss persists after 2 weeks of therapy. Do periodic funduscopic evaluation. Discontinue if carpal tunnel syndrome persists after dosage reduction. Glucose intolerance. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Adverse Reactions |
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Musculoskeletal discomfort, increased tissue turgor, pancreatitis, others. |
| How Supplied |
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Vials (w. diluent)—7 |
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