Monograph Details
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Endocrine System
> Pituitary disorders
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PARLODEL CAPSULES |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Dopamine agonist (ergot deriv). |
| Generic Name |
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Bromocriptine (as mesylate) 5mg. |
| Also |
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• PARLODEL
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| Indications |
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Hyperprolactinemia-associated amenorrhea, galactorrhea, hypogonadism. Prolactin-secreting adenomas. Acromegaly. |
| Children |
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<11 years: not recommended. 11–15 years: initially 1.25mg–2.5mg daily; range 2.5–10mg/day. |
| Adults |
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Take with food. Hyperprolactinemia: initially 1.25–2.5mg/day, may increase every 2–7 days by 2.5mg/day; range 2.5–15mg/day. Acromegaly: 1.25–2.5mg at bedtime for 3 days then increase by 1.25–2.5mg/day every 3–7 days; range 20–30mg/day; max 100mg/day. |
| Contraindications |
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Uncontrolled hypertension. Hypertension of pregnancy. Postpartum lactation. Other ergots. |
| Precautions |
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Evaluate pituitary first. Use barrier contraception until ovulation normalizes; monitor for pregnancy. Post-partum use with severe cardiovascular disease (eg, coronary artery disease). Dementia. MI. Arrhythmias. Cardiovascular, renal, or hepatic disease. Raynaud's syndrome. Discontinue if hypertension, severe headache, or CNS toxicity occurs. Psychosis. Peptic ulcer. GI bleed. Monitor BP. Pregnancy (Cat.B); discontinue if occurs. Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Avoid phenothiazines, alcohol. Potentiates antihypertensives. Caution with dopamine antagonists, butyrophenones, drugs that affect BP. Antagonized by phenothiazines, haloperidol, metoclopramide, pimozide. |
| Adverse Reactions |
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GI upset, headache, dizziness, fatigue, abdominal cramps, drowsiness, hypotension, syncope, rarely: hypertension, seizures, stroke, MI. Acromegaly: also digital vasospasm, GI bleed. |
| How Supplied |
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Tabs, caps—30, 100 |
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