Monograph Details
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Endocrine System
> Pituitary disorders
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LUPRON |
| Manufacturer |
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TAP Pharmaceutical Products, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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GnRH analogue. |
| Generic Name |
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Leuprolide acetate 5 mg/mL; for SC inj; contains benzyl alcohol. |
| Also |
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• LUPRON DEPOT-PED
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| Indications |
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Central precocious puberty. |
| Children |
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Initially 50 micrograms/kg daily as a single SC inj; may increase in increments of 10micrograms daily. |
| Adults |
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Not applicable. |
| Contraindications |
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Pregnancy (Cat.X). |
| Precautions |
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Confirm diagnosis. Monitor hormonal effects within first 4–8 weeks, growth velocity and bone age velocity every 6–12 months. Apprise patient and/or guardian of long-term effects and importance of compliance. Exclude pregnancy before treatment. Nursing mothers: not recommended. |
| Adverse Reactions |
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Transient exacerbation of symptoms, pain, acne, rash, syncope, GI upset, emotional lability, gynecomastia, vaginitis, vaginal discharge, local reactions. |
| How Supplied |
Multidose vial (2.8 mL)—1 (w. syringes)
Depot-PED kit—1 (syringe w. diluent) |
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