Monograph Details
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Endocrine System
> Pituitary disorders
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DDAVP NASAL SPRAY |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Vasopressin (synthetic). |
| Generic Name |
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Desmopressin acetate 10micrograms/spray; nasal spray. |
| Also |
• DDAVP
• DDAVP INJECTION
• DDAVP RHINAL TUBE
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| Indications |
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Central (cranial) diabetes insipidus. Temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. |
| Children |
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<3 months: not recommended. ≥3 months: 5–30 micrograms daily intranasally in 1–2 divided doses. Use rhinal tube for doses <10 micrograms. |
| Adults |
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10–40 micrograms daily intranasally in 1–3 divided doses. Use rhinal tube for doses <10 micrograms. |
| Contraindications |
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Moderate-to-severe renal impairment (CrCl<50mL/min). |
| Precautions |
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Monitor fluid intake, urine volume and osmolality. Fluid/electrolye imbalance (eg, cystic fibrosis). Coronary artery insufficiency. Hypertension. Nasal mucosal changes (nasal forms). Repeated administration of injectable before 48 hrs associated with tachyphylaxis. Very young. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with other pressor agents. |
| Adverse Reactions |
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Nasal congestion or rhinitis (nasal forms), headache, nausea, flushing, abdominal cramps, water intoxication, hyponatremia, changes in blood pressure; seizures in children from plasma hypoosmolality (rare). |
| How Supplied |
Tabs—100
Nasal spray—5mL (50 sprays)
Rhinal tube—2.5mL (w. 2 rhinal tubes)
Amp (1mL)—10 |
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