Monograph Details
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Endocrine System
> Pituitary disorders
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DDAVP INJECTION |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Vasopressin (synthetic). |
| Generic Name |
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Desmopressin acetate 4micrograms/mL; soln for IV infusion after dilution. |
| Also |
• DDAVP
• DDAVP NASAL SPRAY
• DDAVP RHINAL TUBE
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| Indications |
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Central (cranial) diabetes insipidus. Temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Hemostasis in Hemophilia A, von Willebrand's disease (Type I), each with >5% Factor VIII. |
| Children |
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Diabetes insipidus: not recommended. Hemophilia A and von Willebrands: <3 months: not recommended. ≥3 months: as adult. |
| Adults |
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Diabetes insipidus: 2–4 micrograms/day SC or IV in 2 divided doses. If switching stabilized patient, use one-tenth of intranasal dose. Hemophilia A and von Willebrand's: 0.3 micrograms/kg IV over 15–30 minutes. If used preoperatively, give 30 minutes before scheduled procedure. |
| Contraindications |
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Moderate-to-severe renal impairment (CrCl<50mL/min). |
| Precautions |
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Monitor fluid intake, urine volume and osmolality. Fluid/electrolye imbalance (eg, cystic fibrosis). Coronary artery insufficiency. Hypertension. Nasal mucosal changes (nasal forms). Repeated administration of injectable before 48 hrs associated with tachyphylaxis. Very young. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with other pressor agents. |
| Adverse Reactions |
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Nasal congestion or rhinitis (nasal forms), headache, nausea, flushing, abdominal cramps, water intoxication, hyponatremia, changes in blood pressure; seizures in children from plasma hypoosmolality (rare). |
| How Supplied |
Tabs—100
Nasal spray—5mL (50 sprays)
Rhinal tube—2.5mL (w. 2 rhinal tubes)
Amp (1mL)—10 |
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