Monograph Details
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Endocrine System
> Diabetes
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HUMALOG MIX75/25 |
| Manufacturer |
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Lilly, Eli and Company |
| Legal Classification |
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Rx
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| Generic Name |
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Insulin lispro protamine suspension 75% (recombinant), insulin lispro 25% (recombinant) 100 Units/mL; SC inj; contains zinc, m-cresol. |
| Also |
• HUMALOG
• HUMALOG MIX50/50
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| Indications |
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Diabetes. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: SC injection only. Onset approx ≤15 minutes, peak approx 30–90 minutes, duration up to 24 hrs. |
| Precautions |
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Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiated by salicylates, MAOIs, alcohol, sulfa drugs, some ACE inhibitors, drugs that inhibit pancreatic function (eg, octreotide). Antagonized by corticosteroids, isoniazid, niacin, thiazides, phenothiazines, sympathomimetics. Variable effects with β-blockers, clonidine, lithium salts, alcohol. When mixing insulin lispro with other insulins, draw insulin lispro into syringe first and inject mixture immediately. |
| Adverse Reactions |
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Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema. |
| How Supplied |
Humalog Mix75/25, Humalog vials (10mL)—1
Humalog Mix, Humalog prefilled disposable pens—5x3mL
Humalog Mix, Humalog KwikPen (disposable insulin delivery device) (3mL)—5
Humalog cartridges (3mL)—5
HumaPen MEMOIR (inj device, uses Humalog cartridges)—1
HumaPen LUXURA HD (inj device, uses Humalog cartridges)—1 |
| Additional Resources |
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• Related Prescribing Note |
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