Monograph Details
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Endocrine System
> Diabetes
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GLUCOTROL XL |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Sulfonylurea (2nd generation). |
| Generic Name |
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Glipizide 2.5mg, 5mg, 10mg; ext rel tabs. |
| Also |
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• GLUCOTROL
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| Indications |
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Adjunct to diet in type 2 diabetes. |
| Children |
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Not recommended. |
| Adults |
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Do not crush, chew or divide. Initially 5mg with breakfast. Usual range: 5–10mg once daily; max 20mg daily. |
| Contraindications |
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Ketoacidosis. |
| Precautions |
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Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with prolonged therapy. Monitor urine and blood glucose. Impaired GI function or GI narrowing (XL). Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended. |
| Interactions |
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Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers, possibly miconazole. Antagonized by diuretics, steroids, phenothiazines, phenytoin, niacin, sympathomimetics, calcium channel blockers, isoniazid, others. Disulfiram-like reaction with alcohol (rare). |
| Adverse Reactions |
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Increased risk of cardiovascular mortality. Hypoglycemia, cholestatic jaundice, GI disturbances, tremor, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria, transient dizziness, drowsiness, headache. |
| How Supplied |
XL tabs 2.5mg—30
XL tabs 5mg, 10mg—100, 500
Tabs—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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