Monograph Details
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Endocrine System
> Diabetes
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GLUCOTROL |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Sulfonylurea (2nd generation). |
| Generic Name |
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Glipizide 5mg, 10mg; scored tabs. |
| Also |
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• GLUCOTROL XL
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| Indications |
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Adjunct to diet in type 2 diabetes. |
| Children |
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Not recommended. |
| Adults |
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Initially 5mg before breakfast. Elderly or debilitated: initially 2.5mg daily. Increase only if needed per blood glucose by 2.5–5mg every few days. Max 15mg once daily dose. Max 40mg daily in divided doses ½ hour before meals. |
| Contraindications |
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Ketoacidosis. |
| Precautions |
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Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with prolonged therapy. Monitor urine and blood glucose. Impaired GI function or GI narrowing (XL). Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended. |
| Interactions |
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Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers, possibly miconazole. Antagonized by diuretics, steroids, phenothiazines, phenytoin, niacin, sympathomimetics, calcium channel blockers, isoniazid, others. Disulfiram-like reaction with alcohol (rare). |
| Adverse Reactions |
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Increased risk of cardiovascular mortality. Hypoglycemia, cholestatic jaundice, GI disturbances, tremor, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria, transient dizziness, drowsiness, headache. |
| How Supplied |
XL tabs 2.5mg—30
XL tabs 5mg, 10mg—100, 500
Tabs—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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