Monograph Details
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Endocrine System
> Diabetes
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DIABINESE |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Sulfonylurea (1st generation). |
| Generic Name |
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Chlorpropamide 100mg, 250mg; scored tabs. |
| Indications |
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Adjunct to diet in type 2 diabetes. |
| Children |
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Not recommended. |
| Adults |
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Initially 250mg daily. Elderly: initially 100–125mg daily. Titrate dose. Take with breakfast. Max 750mg daily. |
| Contraindications |
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Ketoacidosis. |
| Precautions |
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Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. Monitor urine and blood glucose. Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended. |
| Interactions |
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Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. Disulfiram-like reaction with alcohol. |
| Adverse Reactions |
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Increased risk of cardiovascular mortality. Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria. |
| How Supplied |
100mg—100, 500
250mg—100, 250, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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