Monograph Details
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Endocrine System
> Diabetes
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CAPOTEN |
| Manufacturer |
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Par Pharmaceutical, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Captopril 12.5mg, 25mg, 50mg, 100mg; scored tabs. |
| Indications |
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Diabetic nephropathy in type 1 diabetes with retinopathy. |
| Children |
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Not recommended. |
| Adults |
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Take 1 hr before meals. 25mg 3 times daily. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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See literature. Salt/volume depletion. Dialysis (esp. high-flux membrane). CHF. Aortic stenosis. Monitor WBCs and renal function in renal and collagen vascular disease. Monitor for hyperkalemia in diabetics and renal insufficiency. Surgery. Discontinue if neutropenia, agranulocytosis, angioedema, or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Caution with K+-sparing diuretics and K+-containing supplements. May be antagonized by NSAIDs. Potentiated by diuretics, β-blockers, adrenergic antagonists. May increase lithium levels. May produce false (+) urinary acetone. |
| Adverse Reactions |
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Hypotension, headache, dysgeusia, rash, pruritus, dizziness, fatigue, cough, proteinuria, nephritis, GI upset, hyperkalemia, hyponatremia, back pain, tachycardia, dry mouth, jaundice, somnolence, sweating, sinusitis, impotence, angioedema. |
| How Supplied |
Tabs 25mg, 50mg—100, 1000
12.5mg, 100mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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