Monograph Details
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Endocrine System
> Corticosteroid-responsive disorders
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Prednisone |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Glucocorticoid. |
| Generic Name |
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Prednisone 1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg; scored tabs. |
| Indications |
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Corticosteroid-responsive disorders. |
| Adults and Children |
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See literature. Initially 5–60mg daily. |
| Contraindications |
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Systemic fungal infections. Live vaccines. |
| Precautions |
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Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers. |
| Interactions |
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Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants. |
| Adverse Reactions |
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HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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