Monograph Details
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Endocrine System
> Corticosteroid-responsive disorders
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PEDIAPRED |
| Manufacturer |
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UCB Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Glucocorticoid. |
| Generic Name |
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Prednisolone (as sodium phosphate) 5mg/5mL; sugar-, alcohol- and dye-free; raspberry-flavor soln. |
| Indications |
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Steroid-responsive disorders. |
| Adults and Children |
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See literature. Initially 5–60mg/day. |
| Contraindications |
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Systemic mycoses. Live vaccination. |
| Precautions |
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Tuberculosis. Latent amebiasis. Hypothyroidism. Cirrhosis. Ocular herpes simplex. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Renal insufficiency. Ulcerative colitis if perforation pending. Diverticulitis. Peptic ulcer. Hypertension. Osteoporosis. Diabetes. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Alternate, intermittent or single-daily doses at 8AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Barbiturates, hydantoins, rifampin may decrease effects. Avoid aspirin in hypoprothrombinemia. |
| Adverse Reactions |
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HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. |
| How Supplied |
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Soln—4oz |
| Additional Resources |
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• Related Prescribing Note |
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