Monograph Details
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Endocrine System
> Corticosteroid-responsive disorders
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CORTEF ORAL SUSPENSION |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Gluco/mineralocorticoid. |
| Generic Name |
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Hydrocortisone (as cypionate) 10mg/5mL. |
| Also |
• CORTEF
• SOLU-CORTEF INJECTION
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| Indications |
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Steroid-responsive disorders. |
| Children |
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See literature. Oral: in single or divided doses. Replacement: 0.56mg/kg per day. Other indications: 2–8mg/kg per day. Parenteral: not less than 25mg daily. |
| Adults |
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See literature. Oral: initially 20–240mg daily. Parenteral: initially 100–500mg. |
| Contraindications |
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Systemic mycoses. Live vaccination. Premature infants (inj). |
| Precautions |
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Tuberculosis. Latent amebiasis. Hypothyroidism. Cirrhosis. Ocular herpes simplex. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Renal insufficiency. Ulcerative colitis if perforation pending. Diverticulitis. Peptic ulcer. Hypertension. Osteoporosis. Diabetes. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Alternate, intermittent or single-daily doses at 8AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Barbiturates, hydantoins, rifampin may decrease effects. Avoid aspirin in hypoprothrombinemia. |
| Adverse Reactions |
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HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. |
| How Supplied |
Tabs 5mg—50
10mg, 20mg—100
Susp—4oz
Solu-Cortef 100mg (2mL)—1, 25
250mg (2mL)—1, 25
500mg (4mL), 1g (8mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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