Monograph Details
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Dermatological Disorders
> Skin infections (topicals)
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SILVADENE |
| Manufacturer |
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King Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Sulfonamide antibacterial. |
| Generic Name |
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Silver sulfadiazine 1%; cream. |
| Indications |
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Prophylaxis and treatment of sepsis in 2nd and 3rd degree burns. |
| Children |
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Not recommended. |
| Adults |
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Apply 1–2 times daily aseptically to approximately 1/16 inch depth to cleansed and debrided burns. Reapply promptly if removed. Continue until wound closed. |
| Contraindications |
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Premature infants. Within first 2 months of birth. Late pregnancy. |
| Precautions |
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G6PD deficiency. Impaired renal or hepatic function. Monitor serum sulfa levels and renal function in extensive burns. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Leukopenia increased with concomitant cimetidine. May inactivate debriding enzymes. |
| Adverse Reactions |
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Transient leukopenia, burning sensation, rash, pruritus, fungal overgrowth, interstitial nephritis, systemic sulfonamide reactions. |
| How Supplied |
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Crm—20g, 50g, 85g, 400g, 1kg |
| Additional Resources |
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• Related Prescribing Note |
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