Monograph Details
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Dermatological Disorders
> Rosacea
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ORACEA |
| Manufacturer |
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CollaGenex Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline. |
| Generic Name |
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Doxycycline 40mg (30mg immediate-release beads, 10mg delayed-release beads); caps. |
| Indications |
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Treatment of inflammatory lesions (papules and pustules) of rosacea. |
| Children |
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Not recommended. |
| Adults |
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Take on empty stomach in the morning with sufficient amount of fluids. 40mg once daily. |
| Precautions |
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Do not substitute with other doxycycline products. Renal impairment. Hepatic insufficiency. Monitor blood, renal and hepatic function. Achlorhydria. GI surgery. Predisposition to candidiasis overgrowth. Avoid sun and UV light. Discontinue if superinfection occurs and treat. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended. Not recommended for either gender if conception is planned. |
| Interactions |
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Avoid concomitant methoxyflurane, penicillins, photosensitizers, oral retinoids. Reduced absorption with bismuth subsalicylate, acid pump inhibitors, antacids, calcium, magnesium, iron. May potentiate anticoagulants (eg, warfarin). May antagonize hormonal contraceptives (use back-up contraception). May be antagonized by metabolic enzyme inducers (eg, barbiturates, carbamazepine, phenytoin). |
| Adverse Reactions |
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Sinusitis, superinfection, GI upset, dry mouth, increased blood pressure, blood glucose levels, elevated liver enzymes, BUN; pseudomembranous colitis, autoimmune syndromes (discontinue if occurs), hyperpigmentation, photosensitivity; benign intracranial hypertension, others (see literature). |
| How Supplied |
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Caps—30 |
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