Monograph Details
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Dermatological Disorders
> Psoriasis
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AMEVIVE I.V. |
| Manufacturer |
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Astellas Pharma US, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Immunosuppressant. |
| Generic Name |
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Alefacept 7.5mg/0.5mL; pwd for IV inj after reconstitution; preservative-free. |
| Also |
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• AMEVIVE I.M.
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| Indications |
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Moderate to severe chronic plaque psoriasis in patients who are candidates for systemic or phototherapy. |
| Children |
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Not recommended. |
| Adults |
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7.5mg once weekly as IV bolus or 15mg once weekly as IM inj; both: treat for 12 weeks. May repeat course after 12 treatment-free weeks. |
| Contraindications |
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Lymphopenia. Clinically important infection (eg, HIV). History of systemic malignancy. |
| Precautions |
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Monitor CD4+ counts before and every 2 weeks during therapy; withhold and monitor weekly if CD4+ count <250cells/µL; discontinue if a count of <250cells/µL persists for 4 weeks. History or risk of malignancy; discontinue if malignancy develops. Chronic or history of recurrent infections. Monitor closely if new infection develops during or after treatment; discontinue if serious infection develops. Monitor for hepatic injury; discontinue if signficant clinical signs of liver injury occur. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Do not give with other immunosuppressants or phototherapy. Caution with concurrent live vaccines. |
| Adverse Reactions |
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Pharyngitis, dizziness, cough, nausea, pruritus, myalgia, chills, inj site reactions, cardiovascular events, headache, antibody formation, malignancies, infection (may be serious), anaphylaxis, elevated transaminases, hepatic injury/failure. |
| Extra Text |
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Note: Register pregnant patients exposed to alefacept by calling (866) 263-8483. |
| How Supplied |
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Single-use vials—1, 4 |
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