Monograph Details
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Dermatological Disorders
> Pruritus and dry skin
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ZONALON |
| Manufacturer |
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Doak Dermatologics |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antipruritic. |
| Generic Name |
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Doxepin HCl 5%; crm. |
| Indications |
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Moderate pruritus associated with atopic dermatitis and lichen simplex chronicus. |
| Children |
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Not recommended. |
| Adults |
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Apply thin film to affected area 4 times a day at 3–4 hour intervals for up to 8 days. Do not occlude. |
| Contraindications |
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Untreated narrow-angle glaucoma. Urinary retention. |
| Precautions |
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During or within 14 days of MAOIs. Poor metabolizers may have increased effects. For dermatological use only. Avoid eyes. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Discontinue MAOIs at least 2 weeks before starting. Alcohol, CNS depressants potentiate sedation. May potentiate drugs metabolized by CYP2D6 (e.g., cimetidine, tricyclic antidepressants, SSRIs, phenothiazines, carbamazepine, propafenone, flecainide, encainide, quinidine). |
| Adverse Reactions |
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Drowsiness, dry mouth, thirst, headache, fatigue, dizziness, emotional or taste changes, burning/stinging, pruritus or eczema exacerbation, skin dryness or tightening, parethesias, edema. |
| How Supplied |
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Crm—30g, 45g |
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