Monograph Details
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Dermatological Disorders
> Miscellaneous dermatological conditions
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EFUDEX CREAM |
| Manufacturer |
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Valeant Pharmaceuticals, Inc |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antimetabolite. |
| Generic Name |
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Fluorouracil 5%. |
| Also |
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• EFUDEX
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| Indications |
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Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see literature. |
| Children |
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Not recommended. |
| Adults |
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Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks). |
| Contraindications |
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Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy (Cat.X). |
| Precautions |
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Apply cautiously near eyes, nose, mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Notify patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended. |
| Adverse Reactions |
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Pain or burning at application site, pruritus, irritation, hyperpigmentation. |
| How Supplied |
Soln—10mL (w. drop dispenser)
Crm—25g |
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